Captopril is an angiotensin converting enzyme inhibitor, widely used in management of hypertension. It has very short half life of 2 h and oral bioavailability of 70%. The present investigation is concerned with the development of the floating microspheres of Captopril to target the drug to its absorption site by increasing the residence time of drug in stomach and to control drug release in therapeutic range for longer period of time. Floating microspheres of Captopril were prepared by Non-aqueous solvent evaporation technique using 32- Full factorial design. In this dosage form, hydrophobic water impermeable polymer Ethyl cellulose (EC) for controlling the release of drug and hydrophobic water permeable polymer (Eudragit RL-100) were used for initial release of drug. Optimization process was carried out with respect to various dependent variables like T50%( h),T80% (h),’n’ of Higuchi eq., Pappas eq., release at 6 h. re, release at 18 h etc. and optimized formulations were developed. Among three optimized formulations, results of OF1, OF2 and OF3 closely met to targeted data. This optimized formulation OF3 consisting of drug polymer ratio 1:6 in which 95 % EC and 5 % Eudragit RL -100. And this optimized formulation has shown the better release of drug upto 88% within 24 h periods of time and around 97 % of microspheres retained buoyant for 24 h .Thus optimized formulation has been developed successfully with desired therapeutic effects.
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